Reduced uptake of apoptotic cells by macrophages in Systemic Lupus Erythematosus (SLE): correlates with decreased serum levels of complement
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Reduced uptake of apoptotic cells by macrophages in systemic lupus erythematosus: correlates with decreased serum levels of complement.
BACKGROUND Defects in phagocytosis of apoptotic cells have a role in the pathogenesis of autoimmune diseases. Decrease of phagocytosis of apoptotic cells occurs in systemic lupus erythematosus (SLE). Factors underlying this decrease are, presently, unknown. OBJECTIVE To analyse the expression of relevant membrane receptors of monocyte derived macrophages (MDM) from patients with SLE and asses...
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OBJECTIVE Accumulation of dying and dead cells is thought to be involved in the etiopathogenesis of systemic lupus erythaematosus (SLE). Clearance has been described mainly for apoptotic cells; however, the knowledge of serum factors participating in the phagocytosis of necrotic cells is limited. PATIENTS AND METHODS Sera from 18 patients with SLE and 10 normal healthy donors (NHD), and macro...
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